PARD3 Antibody (aa1141-1190)

Q8TEW0

Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Targets the phosphatase PTEN to cell junctions. Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons.

Polyclonal

PARD3 (HGNC:16051)

H, M, Rat

IF

IHC

PARD3 Antibody detects endogenous levels of total PARD3 protein.

Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.