RTN4 / Nogo Antibody (Internal)

Synthetic peptide

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.

Polyclonal

RTN4 (HGNC:14085)

H, Pr

IHC

IHC

Human RTN4 / Nogo. This antibody is expected to recognize reported isoform A (NP_065393.1) and isoform E (NP_997404.1).

0.5 mg/ml

IHC-P (2.5 µg/ml)