Hersteller |
Abcepta
|
Kategorie |
|
Typ |
Antibody Primary |
Specific against |
other |
Applikationen |
WB, ELISA, IHC-P |
Menge |
50 ug |
Host |
Goat |
ArtNr |
ABC-ALS13073 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Primary Accession |
Q9Y261 |
Antigen Type |
Synthetic peptide |
Application |
WB, IHC-P, E |
Bio Background |
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. |
Bio References |
Yamada S., et al.Diabetologia 43:121-124(2000).Hinokio Y., et al.Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.Navas M.A., et al.Hum. Hered. 50:370-381(2000).Deloukas P., et al.Nature 414:865-871(2001).Wolfrum C., et al.Proc. Natl. Acad. Sci. U.S.A. 100:11624-11629(2003). |
Clonality |
Polyclonal |
Gene ID |
3170 |
Gene Name |
FOXA2 |
Subtitle |
Goat Polyclonal Antibody |
Reactivity |
H, M, Rat, Rb, Ha, Pr, Pig, C, Hs, X, B, Dog |
Legend image 1 |
Anti-FOXA2 antibody IHC of human prostate. |
Type image 1 |
IHC |
Calculated MW |
48306 |
Target/Specificity |
Human FOXA2. This antibody is expected to recognise both reported isoforms. |
Purification |
Immunoaffinity purified |
Concentration (mg/ml) |
0.5 mg/ml |
Reconstitution & Storage |
Store at -20°C. Minimize freezing and thawing. |
Dilution |
ELISA (1:2000), IHC-P (3.75 µg/ml), WB (1-3 µg/ml) |
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