ArtNr |
ABC-ALS11654 |
Hersteller |
Abcepta
|
Menge |
50 ug |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
WB, IHC-P |
Clon |
66C1247.1 |
Specific against |
other |
Host |
Mouse |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
AKT3, PKBG, RAC-gamma serine/threonine-protein kinase, Protein kinase Akt-3, Protein kinase B gamma, RAC-PK-gamma, STK-2, 2.7.11.1, PKB gamma |
Lieferbar |
|
Primary Accession |
Q9Y243 |
Antigen Type |
Synthetic peptide |
Application |
WB, IHC-P |
Bio Background |
AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis. |
Bio References |
Brodbeck D., et al.J. Biol. Chem. 274:9133-9136(1999).Nakatani K., et al.Biochem. Biophys. Res. Commun. 257:906-910(1999).Masure S., et al.Eur. J. Biochem. 265:353-360(1999).Li X., et al.Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases.Wiemann S., et al.Genome Res. 11:422-435(2001). |
Clonality |
Monoclonal |
Gene ID |
10000 |
Gene Name |
AKT3 |
Subtitle |
Mouse Monoclonal Antibody |
Reactivity |
H, M, Rat, Rb, Pr, Pig, C, Hs, B, Dog |
Legend image 1 |
Anti-AKT3 antibody IHC of human brain, cerebellum. |
Type image 1 |
IHC |
Calculated MW |
55775 |
Target/Specificity |
A synthetic peptide corresponding to amino acid residues 119-136 (CSPTSQIDNIGEEEMDAS) of human Akt3, GenBank no. gi|4574744|gb|AAD24196.1|AF135794_1. This sequence is identical in human, mouse, rat, cow, dog, and chicken. |
|
Clone: 66C1247.1 |
Purification |
Protein G purified |
Concentration (mg/ml) |
0.5 mg/ml |
Reconstitution & Storage |
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. |
Dilution |
IHC-P (10 µg/ml), WB (1-2 µg/ml), |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.