ArtNr |
ABC-ALS10792 |
Hersteller |
Abcepta
|
Menge |
50 ug |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
IHC-P |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
FZD4, CD344, Fz-4, FzE4, Frizzled-4, hFz4 |
Lieferbar |
|
Primary Accession |
Q9ULV1 |
Antigen Type |
Synthetic peptide |
Application |
IHC-P |
Bio Background |
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
Bio References |
Kirikoshi H., et al.Biochem. Biophys. Res. Commun. 264:955-961(1999).Kopatz S.A., et al.Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.Ota T., et al.Nat. Genet. 36:40-45(2004).Taylor T.D., et al.Nature 440:497-500(2006).Tanaka S., et al.Proc. Natl. Acad. Sci. U.S.A. 95:10164-10169(1998). |
Clonality |
Polyclonal |
Gene ID |
8322 |
Gene Name |
FZD4 |
Subtitle |
Rabbit Polyclonal Antibody |
Reactivity |
H, M, Rb, Ha, Pr, Pig, C, Hs, B, Dog |
Legend image 1 |
Anti-FZD4 / Frizzled 4 antibody IHC of human Pancreas, Carcinoma. |
Type image 1 |
IHC |
Legend image 2 |
Anti-FZD4 / Frizzled 4 antibody IHC of human Skin, Melanoma. |
Type image 2 |
IHC |
Calculated MW |
59881 |
Target/Specificity |
Human FZD4 / Frizzled 4. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
Purification |
Immunoaffinity purified |
Concentration (mg/ml) |
1 mg/ml |
Reconstitution & Storage |
Long term: -70°C; Short term: +4°C |
Dilution |
IHC-P (25 µg/ml) |
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