Anti-CD162 (Selectin P Ligand) Antibody

Recombinant protein

CD162 glycoprotein functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response.

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Mouse Monoclonal Antibody

Formalin-fixed, paraffin-embedded human Spleen stained withCD162 Monoclonal Antibody (PSGL1/1601).

Formalin-fixed, paraffin-embedded human Tonsil stained withCD162 Monoclonal Antibody (PSGL1/1601).

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