Vergleich

Goat Anti-TIRAP / Mal (Isoform b) Antibody

ArtNr ABC-AF2092a
Hersteller Abcepta
Menge 100 ug
Kategorie
Typ Antibody Primary
Applikationen WB, ELISA
Specific against other
Host Goat
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products TIRAP, MAL, MyD88 adapter-like protein, Toll/interleukin-1 receptor domain-containing adapter protein, TIR domain-containing adapter protein, Adaptor protein Wyatt, MyD88-2
Lieferbar
Primary Accession
P58753
Antigen Type
Synthetic Peptide
Application
WB, E
Bio Background
The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
Bio References
Toll-like receptor and TIRAP gene polymorphisms in pulmonary tuberculosis patients of South India. Selvaraj P, et al. Tuberculosis (Edinb), 2010 Sep. PMID 20797905.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.
Dengue hemorrhagic fever is associated with polymorphisms in JAK1. Silva LK, et al. Eur J Hum Genet, 2010 Jun 30. PMID 20588308.
Genetic variation of innate immune genes in HIV-infected african patients with or without oropharyngeal candidiasis. Plantinga TS, et al. J Acquir Immune Defic Syndr, 2010 Sep 1. PMID 20577092.
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts. Kumpf O, et al. Crit Care, 2010. PMID 20525286.
Clonality
Polyclonal
Gene ID
114609
Gene Name
TIRAP
Subtitle
Peptide-affinity purified goat antibody
Reactivity
H
Legend image 1
AF2092a (1 µg/ml) staining of Human Liver lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Type image 1
WB
Other Accession
NP_683708; 114609;
Concentration (mg/ml)
100ug/200ul

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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