ArtNr |
ABC-AF1784a |
Hersteller |
Abcepta
|
Menge |
100 ug |
Kategorie |
|
Typ |
Antibody Primary |
Applikationen |
IHC, ELISA |
Specific against |
other |
Host |
Goat |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
PPY, PH, PNP, Pancreatic hormone, PP, PI, Pancreatic prohormone, Pancreatic prohormone, Pancreatic polypeptide, Pancreatic icosapeptide, Obinepitide |
Lieferbar |
|
Primary Accession |
P01298 |
Antigen Type |
Synthetic Peptide |
Application |
IHC, E |
Bio Background |
This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. |
Bio References |
Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men. Campbell CD, et al. Diabetes, 2007 May. PMID 17325259.Single nucleotide polymorphisms in the neuropeptide Y2 receptor (NPY2R) gene and association with severe obesity in French white subjects. Siddiq A, et al. Diabetologia, 2007 Mar. PMID 17235527.Plasma pancreatic polypeptide levels are associated with differences in body fat distribution in human subjects. Tong J, et al. Diabetologia, 2007 Feb. PMID 17171555.Human pancreatic polypeptide has a marked diurnal rhythm that is affected by ageing and is associated with the gastric TFF2 circadian rhythm. Johns CE, et al. Peptides, 2006 Jun. PMID 16359755.A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control. Schmidt PT, et al. J Clin Endocrinol Metab, 2005 Sep. PMID 15998783. |
Clonality |
Polyclonal |
Gene ID |
5539 |
Gene Name |
PPY |
Subtitle |
Peptide-affinity purified goat antibody |
Reactivity |
H, M |
Legend image 1 |
AF1784a (3 µg/ml) staining of paraffin embedded Human Pancreas. Microwaved antigen retrieval with Tris/EDTA buffer Ph9, HRP-staining. |
Type image 1 |
IHC |
Legend image 2 |
AF1784a (5 µg/ml) staining of paraffin embedded Human Pancreas. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. |
Type image 2 |
IHC |
Legend image 3 |
AF1784a (5 µg/ml) staining of paraffin embedded Human Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. |
Type image 3 |
IHC |
Other Accession |
NP_002713; 5539; |
Predicted |
Rat, Dog |
Concentration (mg/ml) |
100ug/200ul |
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