Vergleich

Goat Anti-MC2R / ACTHR Antibody

ArtNr ABC-AF1658a
Hersteller Abcepta
Menge 100 ug
Kategorie
Typ Antibody Primary
Applikationen WB, ELISA
Specific against other
Host Goat
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products MC2R, ACTHR, ACTH receptor, ACTH-R, Adrenocorticotropic hormone receptor, Adrenocorticotropin receptor, MC2-R, Melanocortin receptor 2
Lieferbar
Primary Accession
Q01718
Antigen Type
Synthetic Peptide
Application
WB, E
Bio Background
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.
Bio References
Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Canzian F, et al. Hum Mol Genet, 2010 Oct 1. PMID 20634197.
Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: results from the EPIFUND study. Holliday KL, et al. J Psychosom Res, 2010 May. PMID 20403506.
ACTH receptor (MC2R) promoter variants associated with infantile spasms modulate MC2R expression and responsiveness to ACTH. Ding YX, et al. Pharmacogenet Genomics, 2010 Feb. PMID 20042918.
Role of asparagine-linked glycosylation in cell surface expression and function of the human adrenocorticotropin receptor (melanocortin 2 receptor) in 293/FRT cells. Roy S, et al. Endocrinology, 2010 Feb. PMID 20022931.
Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency. Dias RP, et al. Eur J Endocrinol, 2010 Feb. PMID 19903795.
Clonality
Polyclonal
Gene ID
4158
Gene Name
MC2R
Subtitle
Peptide-affinity purified goat antibody
Reactivity
H
Legend image 1
AF1658a (1 µg/ml) staining of Human Skin lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Type image 1
WB
Other Accession
NP_000520; 4158;
Concentration (mg/ml)
100ug/200ul

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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