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HDAC2 Antibody (S394)

HDAC2 Antibody (S394)

ArtNr	ABC-AE1014a
Hersteller	Abcepta
Menge	0.1 mg
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.
Applikationen	WB, IF, IHC
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	HDAC2, HD2, Histone deacetylase 2
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Primary Accession	Q92769
Application	WB, IHC, IF
Bio Background	This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
Bio References	Combination of polymorphisms within the HDAC1 and HDAC3 gene predict tumor recurrence in hepatocellular carcinoma patients that have undergone transplant therapy. Yang Z, et al. Clin Chem Lab Med, 2010 Aug 24. PMID 20731616. Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086. Differential histone deacetylase mRNA expression patterns in amyotrophic lateral sclerosis. Janssen C, et al. J Neuropathol Exp Neurol, 2010 Jun. PMID 20467334. HDAC2 promotes eIF4E sumoylation and activates mRNA translation gene specifically. Xu X, et al. J Biol Chem, 2010 Jun 11. PMID 20421305. Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma. Adams H, et al. Expert Opin Ther Targets, 2010 Jun. PMID 20415600.
Clonality	Polyclonal
Gene ID	3066
Gene Name	HDAC2 (HGNC:4853)
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M, Rat
Legend image 1	Western blot analysis of extracts from HT-29 cells untreated or treated with UV (20min), using HDAC2 Antibody (S394) (#AE1014a, Lane 1 and 2) and Phospho-HDAC2-S394 Antibody (#AE1014b, Lane 3 and 4).
Type image 1	WB
Dilution image 1	1:500~1:1000
Legend image 2	Immunohistochemical analysis of paraffin- embedded human breast carcinoma tissue using HDAC2 Antibody (S394) (#AE1014a).
Type image 2	IHC
Dilution image 2	1:50~1:100
Legend image 3	Immunofluorescence staining of methanol-fixed HeLa cells using HDAC2 Antibody (S394) (#AE1014a, Red).
Type image 3	IF
Dilution image 3	1:100~200
Isotype	Rabbit IgG
Target/Specificity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
NCBI Accession	NP_001518.3
Concentration (mg/ml)	1mg/ml
Sequence	Peptide sequence around aa. 392~396 (E-D-S-G-D), according to the protein NP_001518.2

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ABC-AE1014a-datasheet.pdf

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Menge: 0.1 mg

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Lieferung vsl. bis 04.10.2024

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