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C-Kit Antibody (Y721)

C-Kit Antibody (Y721)

ArtNr	ABC-AE1008a
Hersteller	Abcepta
Menge	0.1 mg
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.
Applikationen	WB
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	KIT, SCFR, Mast/stem cell growth factor receptor Kit, Piebald trait protein, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, p145 c-kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, CD117, PBT
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Primary Accession	P10721
Application	WB
Bio Background	This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.
Bio References	Efficacy evaluation of imatinib treatment in patients with gastrointestinal stromal tumors: a meta-analysis. Chen P, et al. World J Gastroenterol, 2010 Sep 7. PMID 20806443. KIT polymorphisms and mutations determine responses of neoplastic mast cells to bafetinib (INNO-406). Peter B, et al. Exp Hematol, 2010 Sep. PMID 20685234. Prognostic relevance of KIT and PDGFRA mutations in gastrointestinal stromal tumors. Braggio E, et al. Anticancer Res, 2010 Jun. PMID 20651400. Promoter polymorphisms and methylation of E-cadherin (CDH1) and KIT in gastric cancer patients from northern Brazil. Borges Bdo N, et al. Anticancer Res, 2010 Jun. PMID 20651373. Expression of stem cell factor/c-kit signaling pathway components in diabetic fibrovascular epiretinal membranes. Abu El-Asrar AM, et al. Mol Vis, 2010 Jun 15. PMID 20596251.
Clonality	Polyclonal
Gene ID	3815
Gene Name	KIT
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H, M, Rat
Legend image 1	Western blot analysis of extract from A431 cell treated with EGF(200ng/ml, 30min), using C-Kit Antibody (Y721) (#AE1008a, Lane 1 and 2).
Type image 1	WB
Dilution image 1	1:500~1:1000
Isotype	Rabbit IgG
Target/Specificity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
NCBI Accession	NP_000213.1; NP_001087241.1
Concentration (mg/ml)	1mg/ml
Sequence	Peptide sequence around aa.719~723(N-E-Y-M-D), according to the protein NP_000213.1

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ABC-AE1008a-datasheet.pdf

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Menge: 0.1 mg

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Lieferung vsl. bis 04.10.2024

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