APG7/ATG7 Antibody

Q641Y5

Autophagy, the process of bulk degradation of cellular proteins thro µgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) thro µgh phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog (4). In mammalian cells, APG7 is essential for autophagy conj µgation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles. It has been s µggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death.

312647

Rabbit Polyclonal Antibody

NP_001012097