ArtNr |
ABC-ABO11277 |
Hersteller |
Abcepta
|
Menge |
100 ug |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Lyophilized |
Applikationen |
WB, ICC, IHC-P, IHC-F |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
NRG1, Heregulin, HRG, ARIA, GGF, HGL, HRGA, NDF, SMDF, Pro-neuregulin-1, membrane-bound isoform, Neuregulin-1, Acetylcholine receptor-inducing activity, Breast cancer cell differentiation factor p45, Glial growth factor, Neu differentiation factor, Sensory and motor neuron-derived factor, Pro-NRG1 |
Lieferbar |
|
Primary Accession |
Q02297 |
Application |
WB, IHC-P, IHC-F, ICC |
Clonality |
Polyclonal |
Gene ID |
3084 |
Reactivity |
H, M, Rat |
Legend image 1 |
Anti-NRG1 antibody, ABO11277, IHC(P)IHC(P): Rat Intestine Tissue |
Type image 1 |
IHC |
Dilution image 1 |
0.5-1 µg/ml |
Legend image 2 |
Anti-NRG1 antibody, ABO11277, IHC(P)IHC(P): Human Intestinal Cancer Tissue |
Type image 2 |
IHC |
Dilution image 2 |
0.5-1 µg/ml |
Legend image 3 |
Anti-NRG1 antibody, ABO11277, Western blottingLane 1: Rat Spleen Tissue LysateLane 2: Rat Kidney Tissue LysateLane 3: Rat Brain Tissue LysateLane 4: HELA Cell LysateLane 5: SMMC Cell Lysate |
Type image 3 |
WB |
Dilution image 3 |
0.1-0.5 µg/ml |
Legend image 4 |
Anti-NRG1 antibody, ABO11277, IHC(F)IHC(F): Rat Intestine Tissue |
Type image 4 |
IHC |
Dilution image 4 |
0.5-1 µg/ml |
Legend image 5 |
Anti-NRG1 antibody, ABO11277, ICCICC: HELA Cell |
Type image 5 |
ICC |
Calculated MW |
70392 |
Reconstitution |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Description |
Rabbit IgG polyclonal antibody for Pro-neuregulin-1, membrane-bound isoform(NRG1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human; Mouse; Rat. |
Protein Function |
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. . |
Subcellular Localization |
Pro-neuregulin-1, membrane-bound isoform: Cell membrane; Single-pass type I membrane protein. Does not seem to be active. |
Tissue Specificity |
Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells; in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. . |
Protein Name |
Pro-neuregulin-1, membrane-bound isoform |
Contents |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Immunogen |
A synthetic peptide corresponding to a sequence at the C-terminus of human NRG1(617-636aa RFSTQEEIQARLSSVIANQD), different from the related rat and mouse sequences by one amino acids. |
Purification |
Immunogen affinity purified. |
Cross Reactivity |
No cross reactivity with other proteins |
Storage |
At -20?C for one year. After r?Constitution, at 4?C for one month. It?Can also be aliquotted and stored frozen at -20?C for a longer time.Avoid repeated freezing and thawing. |
Concentration (mg/ml) |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Sequence Similarities |
Belongs to the neuregulin family. |
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