ArtNr |
ABC-ABO10876 |
Hersteller |
Abcepta
|
Menge |
100 ug |
Kategorie |
|
Typ |
Antibody Primary |
Format |
Lyophilized |
Applikationen |
WB |
Specific against |
other |
Host |
Rabbit |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Similar products |
DAPK2, Death-associated protein kinase 2, DAP-kinase-related protein 1, DAP kinase 2, 2.7.11.1, DRP-1 |
Lieferbar |
|
Primary Accession |
Q9UIK4 |
Application |
WB |
Clonality |
Polyclonal |
Gene ID |
23604 |
Reactivity |
H, M, Rat |
Legend image 1 |
Anti-DAP Kinase 2 antibody, ABO10876, Western blottingAll lanes: Anti DAP Kinase 2 (ABO10876) at 0.5ug/mlLane 1: U87 Whole Cell Lysate at 40ugLane 2: MCF-7 Whole Cell Lysate at 40ugLane 3: SMMC Whole Cell Lysate at 40ugPredicted bind size: 43KDObserved bind size: 43KD |
Type image 1 |
WB |
Dilution image 1 |
0.1-0.5 µg/ml |
Calculated MW |
42898 |
Reconstitution |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Description |
Rabbit IgG polyclonal antibody for Death-associated protein kinase 2(DAPK2) detection. Tested with WB in Human; Mouse; Rat. |
Protein Function |
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation. |
Subcellular Localization |
Cytoplasm. Cytoplasmic vesicle, autophagosome lumen. |
Tissue Specificity |
Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitously expressed in all tissue types examined with high levels in heart, lung and skeletal muscle. It is expressed abundantly in cells differentiated toward granulocytes and low in undifferentiated, normal and leukemic hematopoietic cells and monocytes/macrophages. . |
Protein Name |
Death-associated protein kinase 2(DAP kinase 2) |
Contents |
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. |
Immunogen |
A synthetic peptide corresponding to a sequence at the C-terminus of human DAP Kinase 2(289-308aa DNQQAMVRRESVVNLENFRK), different from the related mouse and rat sequences by two amino acids. |
Purification |
Immunogen affinity purified. |
Cross Reactivity |
No cross reactivity with other proteins |
Storage |
At -20?C for one year. After r?Constitution, at 4?C for one month. It?Can also be aliquotted and stored frozen at -20?C for a longer time.Avoid repeated freezing and thawing. |
Concentration (mg/ml) |
Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Sequence Similarities |
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. |
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