Mouse Monoclonal Antibody to DCX

Catalog Number: sAP-0731
Product Name: Mouse Monoclonal Antibody to DCX
Target Molecle: DCX
Aliases: DC; DBCN; LISX; SCLH; XLIS
Species: Human
MW: 49.3kDa
Enterez GeneID: 1641
General Information: This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
Immunogen: Purified recombinant fragment of human DCX (AA: 362-411) expressed in E. Coli. ; ;
Clone: MM2G5;
Isotype: Mouse IgG1
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage: Reconstitued with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000; IHC: 1 to 200 - 1 to 1000; ICC: 1 to 200 - 1 to 1000; FCM: 1 to 200 - 1 to 400
References: 1.J Lipid Res. 2010 Oct; 51(10):3055-61. ; 2.Thromb Res. 2010 Sep; 126(3):222-6. ;