Mouse Monoclonal Antibody to NEDD8

Catalog Number: sAP-0665
Product Name: Mouse Monoclonal Antibody to NEDD8
Target Molecle: NEDD8
Aliases: NEDD-8
Species: Human
MW: 9kDa
Enterez GeneID: 4738
General Information: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
Immunogen: Purified recombinant fragment of human NEDD8 expressed in E. Coli. ;
Clone: MM5B8;
Isotype: Mouse IgG1
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage: Reconstitued with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000; IHC: 1 to 200 - 1 to 1000; ICC: 1 to 200 - 1 to 1000; FCM: 1 to 200 - 1 to 400
References: 1. Cell. 2009 Jul 23; 138(2):389-403. ; 2. Biochem Biophys Res Commun. 2009 Apr 10; 381(3):443-7. ;