Mouse Monoclonal Antibody to GCK

Catalog Number: sAP-0593
Product Name: Mouse Monoclonal Antibody to GCK
Target Molecle: GCK
Aliases: GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3
Species: Human
MW: 52kDa
Enterez GeneID: 2645
General Information: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Immunogen: Purified recombinant fragment of human GCK expressed in E. Coli. ;
Clone: MM4G6;
Isotype: Mouse IgG1
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage: Reconstitued with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000
References: 1. J Biol Chem. 2009 Dec 4; 284(49):34145-56. ; 2. Cloning Stem Cells. 2009 Sep; 11(3):427-35.