Hersteller |
American Research Products
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Menge |
100 ug |
ArtNr |
ARP-11-IL-16HT-100 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Description |
Interleukin-16 (IL16) is an immunomodulatory cytokine, which induces lymphocyte migration, expression of proinflammatory IL-1beta, IL6 and tumour necrosis factor-alpha (TNFalpha), and modulates apoptosis. This protein is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. Also, several central nervous system diseases and may play a role in promoting inflammatory responses. Recombinant human IL16, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Form |
Liquid in 20mM Tris pH 8.0, 1mM DTT, 10%glycerol |
Storage |
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Synonyms |
LCF, prIL-16, FLJ16806, FLJ42735, FLJ44234, HST19289, IL 16, Lymphocyte chemoattractant factor, HGNC:5980, Interleukin 16 precursor, PrIL16, |
Concentration |
1 mg/ml (determined by Bradford assay) |
NCBI |
NP_004504 |
References |
- Bernstein HB., et al. (2006) J Immunol. 177(6):3669-76.
- McFadden C J., et al. (2007) J Immunol. 179(10):6439-45.
|
Antigen Recognized in Species |
Human |
Purity |
>, 95% by SDS - PAGE |
Molecular Weight |
15.5kDa (150aa), confirmed by MALDI-TOF. |
Amino Acid Sequence |
MGSSHHHHHH SSGLVPRGSH MPDLNSSTDS AASASAASDV SVESTAEATV CTVTLEKMSA GLGFSLEGGK GSLHGDKPLT INRIFKGAAS EQSETVQPGD EILQLGGTAM QGLTRFEAWN IIKALPDGPV TIVIRRKSLQ SKETTAAGDS |
Gene Category |
Hormones &, Cytokines |
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