Hersteller |
American Research Products
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Menge |
0.5 mg |
ArtNr |
ARP-01-P1556-0.5 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Description |
F11R, also known as CD321, belongs to the immunoglobulin superfamily. It seems to plays a role in epithelial tight junction formation. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. F11R protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Recombinant human F11R protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Form |
Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.15M NaCl, 1mM DTT |
Storage |
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Synonyms |
Junctional adhesion molecule A, CD321, JAM, JAM1, JAMA, JCAM, KAT, PAM-1 |
Concentration |
1 mg/ml (determined by BCA assay) |
NCBI |
NP_058642 |
References |
Murakami, M., et al. (2011) PLoS ONE 6 (6), E21242 |
Antigen Recognized in Species |
Human |
Purity |
>, 90% by SDS - PAGE |
Molecular Weight |
25.8kDa (238aa), confirmed by MALDI-TOF |
Amino Acid Sequence |
MGSSHHHHHH SSGLVPRGSH MGSHMLGSVT VHSSEPEVRI PENNPVKLSC AYSGFSSPRV EWKFDQGDTT RLVCYNNKIT ASYEDRVTFL PTGITFKSVT REDTGTYTCM VSEEGGNSYG EVKVKLIVLV PPSKPTVNIP SSATIGNRAV LTCSEQDGSP PSEYTWFKDG IVMPTNPKST RAFSNSSYVL NPTTGELVFD PLSASDTGEY SCEARNGYGT PMTSNAVRME AVERNVGV |
Gene Category |
Cytoskeleton |
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