ArtNr |
ARP-01-2145-100 |
Hersteller |
American Research Products
|
Menge |
100 ug |
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Lieferbar |
|
Description |
AHSP(Alpha-hemoglobin stabilizing protein), also known as ERAF(Erythroid associated factor), is an erythroid-specific protein that acts as a chaperone to prevent the aggregation of alpha-hemoglobin during normal erythroid cell development. It specifically protects free alpha-hemoglobin from precipitation in live cells and in solution. This protein is downregulated in transmissible spongiform encephalopathies (TSEs). It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia. Recombinant AHSP protein was expressed in E.coli and purified by using conventional chromatography techniques. |
Form |
Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 10% glycerol |
Storage |
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Synonyms |
ERAF, EDRF, Alpha-hemoglobin stabilizing protein Alpha hemoglobin stabilizing protein, Erythroid associated factor, Erythroid differentiation associated factor, Erythroid differentiation related factor, |
Concentration |
1 mg/ml (determined by Bradford assay) |
NCBI |
NP_057717 |
References |
- Dos Santos CO., et al. (2008) J Biol Chem. 283(40):26956-64.
- Sekijima Y., et al. (2005) Cell. 121(1):73-85.
|
Antigen Recognized in Species |
Human |
Purity |
>, 95% by SDS - PAGE |
Molecular Weight |
11.8 kDa (102aa), confirmed by MALDI-TOF. |
Amino Acid Sequence |
MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SS |
Gene Category |
Heat Shock Proteins |
Endotoxin Level |
<, 1.0 EU per 1 microgram of protein (determined by LAL method) |
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