ArtNr |
ARP-01-1783-1-0.5 |
Hersteller |
American Research Products
|
Menge |
0.5 mg |
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Lieferbar |
|
Description |
CDK2AP1 is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. Also, interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes. Recombinant CDK2AP1 protein was expressed in E.coli and purified by using conventional chromatography techniques. |
Form |
Liquid. 20mM Tris-HCl buffer (pH8.0) containing 50% glycerol, 2mM DTT |
Storage |
Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles. |
Synonyms |
CDKAP1, DOC1, CDKA1, Cyclin-dependent kinase 2 associated protein 1 CDK2 A1, CDK2 associated protein 1, CDK2AP1, Cyclin dependent kinase 2 associated protein 1 Deleted in oral cancer 1, DOC 1, DOC 1 related protein, DOC 1R, DOC1R, Putative oral cancer suppressor. |
Concentration |
0.25 mg/ml (determined by Bradford assay) |
NCBI |
NP_004633 |
References |
- Tsuji T., et al. (1998) J Biol Chem. 273(12):6704-9.
- Hu MG., et al. (2004) Cancer Res. 64(2):490-9.
|
Antigen Recognized in Species |
Human |
Purity |
>, 95% by SDS - PAGE |
Molecular Weight |
16.6kDa (152aa), confirmed by MALDI-TOF. |
Amino Acid Sequence |
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSY KPNLAAHMPA AALNAAGSVH SPSTSMATSS QYRQLLSDYG PPSLGYTQGT GNSQVPQSKY AELLAIIEEL GKEIRPTYAG SKSAMERLKR GIIHARGLVR ECLAETERNA RS |
Gene Category |
Cell Cycle |
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