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Anti-Colorectal Carcinoma

Anti-Colorectal Carcinoma

ArtNr	ARP-29-T40022
Hersteller	American Research Products
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	IHC
Clon	Y94
Specific against	other
Host	Mouse
Isotype	IgG1 kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Lieferbar
Description	Mouse monoclonal antibody to human colorectal carcinoma
Background	Colorectal carcinoma is the cancer developed in the colon or rectum of the digestive system. In developed countries, it is the most common cancer in aging population. Genetic deposition and a less active life style contribute to the development of the cancer. Molecular pathological study showed that altered Wnt-APC-b-catenim signalling pathway, mutated p53, and deactivated TGF-b and DCC (Deleted in Colon Cancer) are involved with the pathogenesis. The cancer is currently screened with a fecal occult blood test in people over 50 years old and the malignancy is confirmed by tumour biopsy. The search for specific biomarker for non-invasive test is still ongoing. Tumour associated antigen, TAG-72, is a high molecular weight glycoprotein found at the cell surface in a variety of cancers including gastric cancer, ovarian cancer, colon cancer, breast cancer and pancreatic cancer. It has been used as a tumour marker and therapeutic target for cancer treatment.
Immunogen	Human colorectal carcinoma
Form	Purified, in 0.01M PBS, pH7.0
Specificity	The selected monoclonal antibody reacts with frozen and formalin-fixed, paraffin-embedded human colorectal carcinoma tissues, but does not react with normal adult tissues tested such as liver, colon, breast, stomach, lymph node, and kidney. This antibody can detect the presence of the tumor-associated antigen in the serum of patients with colorectal carcinoma, and was shown to react with mucin-like oncofetal pancarcinoma antigen, glycoprotein TAG-72 (MW: 220-400kDa.)
Storage	Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.
Concentration	1 mg/ml
Interest Field	Oncology
Antigen Recognized in Species	Human, others not tested

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Menge: 100 ug

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Lieferung vsl. bis 20.09.2024

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