ArtNr |
ARP-23-B0045 |
Hersteller |
American Research Products
|
Menge |
25 ug |
Kategorie |
|
Typ |
Antibody Monoclonal |
Applikationen |
WB |
Clon |
Naipa-1 |
Specific against |
other |
Host |
Mouse |
Isotype |
IgG2b kappa |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Lieferbar |
|
Description |
The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK. |
Immunogen |
Recombinant mouse NAIP5 (BIR2 domain/aa 159-227). |
Form |
Purified, in PBS containing 10% glycerol and 0.02% sodium azide. |
Specificity |
Recognizes mouse NAIP1, 2 and 5. Not tested on mouse NAIP6 and mouse NAIP7 but should also work due to high homology in the BIR2 domain. |
Working Dilution |
Optimal conditions must be determined individually for each application. |
Storage |
2-8C immediate use, or -20C (aliquote) |
Synonyms |
Neuronal Apoptosis Inhibitory Protein 1, 2, 5, Baculoviral IAP Repeat-containing Protein 1a, 1b, 1e, Birc 1a, 1b, 1e |
Concentration |
1mg/ml |
Antigen Recognized in Species |
Mouse |
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