Anti-CRKL

CRKL(v-crk sarcoma virus CT10 oncogene homolog (avian)-like) also called ONCOGENEA CRKL, encodes a 303-amino acid polypeptide with a predicted molecular mass of 36 kD. WhileA CRKLA is not the human homolog of CRK, it is similar to protein-tyrosine kinases with SH2 and SH3 (src homology) domains. By fluorescence in situ hybridization, A theA CRKLA gene is localized to chromosome 22q11, centromeric of the chronic myelogenous leukemia breakpoint region. Senechal et al. (1996)A showed thatA CRKLA becomes phosphorylated when overexpressed, activates Ras-dependent and JNK pathways, and transforms fibroblasts. The authors also foundA CRKLA to be a substrate for the BCR-ABL tyrosine kinase, leading them to conclude thatCRKLA is a tyrosine kinase and an oncogene. CrklA was required for normal cellular responses to Fgf8, including survival and migration, Erk activation, and target gene expression.

Lyophilized

2-8C. For long term -20C after reconstitution.

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.