ArtNr |
ARP-10-P1665-1 |
Hersteller |
American Research Products
|
Menge |
200 ul |
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
other |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Lieferbar |
|
Description |
Rabbit IgG polyclonal antibody for NACHT, LRR and PYD domains-containing protein 3 (NLRP3) detection. Tested with WB, IHC-P in Human, Mouse, Rat. |
Background |
NLRP3(NLR FAMILY, PYRIN DOMAIN-CONTAINING 3), also known as CIAS1, CRYOPYRIN, NALP3 or PYPAF1, is a protein that in humans is encoded by the NLRP3 (NOD-like receptor family, pryin domain containing 3) gene. The NLRP3 gene encodes a pyrin-like protein expressed predominantly in peripheral blood leukocytes. And the NLRP3 gene is mapped on 1q44. NLRP3 interacts with apoptosis-associated speck-like protein containing a CARD (ASC). The encoded protein may play a role in the regulation of inflammation and apoptosis. Mutation of the NALP3 nucleotide-binding domain reduced ATP binding, CASP1 activation, IL1B production, cell death, macromolecular complex formation, self-association, and association with ASC. Consistent with an essential role for Nlrp3 inflammasomes in antifungal immunity, Gross et al.showed that Nlrp3-deficient mice are hypersusceptible to C. albicans infection. Activation of the NLRP3 inflammasome in response to virus or to RNA was dependent upon lysosomal maturation and reactive oxygen species production in human cells. The NLRP3 inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance. |
Immunogen |
A synthetic peptide corresponding to a sequence at the N-terminal of human NLRP3, different from the related rat and mouse sequences by one amino acid. |
Form |
Purified, in buffer containing 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. |
Specificity |
Human, Mouse, Rat. No cross reactivity with other proteins. |
Working Dilution |
WB 1:200 - 1:1000, IHC-P 1:100 - 1:200, Optimal dilutions should be determined by end user. |
Storage |
At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time.Avoid repeated freezing and thawing. |
Synonyms |
Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1 |
Uniprot ID |
Q96P20 |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.