ArtNr |
ARP-01-2702 |
Hersteller |
American Research Products
|
Menge |
200 ul |
Kategorie |
|
Typ |
Antibody Monoclonal |
Applikationen |
WB, IF, ELISA |
Clon |
AT21S5 |
Specific against |
Human |
Host |
Mouse |
Isotype |
IgG2b kappa |
Citations |
Shahrokni A, et al., (2009) Clin Colorectal Cancer 8(4):231-4 Henriquez-Hernandez LA, et al., (2009) Oncol Rep 22(6):1425-33 Colavito D, et al., (2009) Cancer Chemother Pharmacol 64(6):1195-200 |
NCBI |
NP_001062 |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
HST422, TMS, TS, d TMP synthase, EC 2.1.1.45, MGC88736, Thymidylate synthase, Thymidylate synthetase, Tsase, TYMS, TYMS protein, Tyms thymidylate synthetase, |
Lieferbar |
|
Description |
The methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dMTP) is an essential step for the formation of thymine nucleotides. This process is catalyzed by thymidylate synthase (TS or TYMS). TYMS is an intracellular enzyme that provides the sole de novo source of thymidylate in activity highest proliferating cells. Being the exclusive source of dTMP, TS is also an important target for anticancer agents such as 5-fluorouracil (5-FU). 5-FU acts as a TS inhibitor and is active against solid tumors such as colon, breast, head and neck. TS expression may be useful in predicting overall patient survival, but the prognostic value of TS expression continues to be a subject of investigation for different types of cancers. |
Immunogen |
Recombinant TYMS (1-313aa) purified from E. coli |
Form |
Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide |
Working Dilution |
Optimal dilution should be performed by user. |
Storage |
Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles. |
Concentration |
0.1 mg/ml |
Interest Field |
Cancer |
Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.
Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.