Vergleich

INS-1 cells

ArtNr C0018007
Hersteller Addexbio
Menge One Frozen vial
Kategorie
Typ Tumour Cells
Specific against Rat (Rattus norvegicus)
Dry ice Yes
Citations 1.Asfari, M., Janjic, D., Meda, P. et al. (1992). Establishment of 2-mercaptoethanol-dependent differentiated insulin- secreting cell lines. Endocrinology 130, 167-178.
2. Chang TJ, Tseng HC, Liu MW, Chang YC, Hsieh ML, Chuang LM. Glucagon-like peptide-1 prevents methylglyoxal-induced apoptosis of beta cells through improvingmitochondrial function and suppressing prolonged AMPK activation.Sci Rep. 2016 Mar 21;6:23403. doi: 10.1038/srep23403. PMID: 26997114
3.Fortin JS, Benoit-Biancamano MO. Inhibition of islet amyloid polypeptide aggregation and associated cytotoxicity by nonsteroidal anti-inflammatory drugs. Can J Physiol Pharmacol. 2016 Jan;94(1):35-48. PMID: 26524404
4. Fortin JS, Benoit-Biancamano MO. In vitro evaluation of hypoglycemic agents to target human islet amyloid polypeptide: a key protein involved in amyloid deposition and beta-cell loss. Can J Diabetes. 2015 Oct;39(5):373-382. PMID: 25862064
5. Bronsart LL, Stokes C, Contag CH.Chemiluminescence Imaging of Superoxide Anion Detects Beta-Cell Function and Mass.PLoS One. 2016 Jan 11;11(1):e0146601. PMID: 26752052
6. Fortin JS, Benoit-Biancamano MO. Wildlife sequences of islet amyloid polypeptide (IAPP) identify critical species variants for fibrillization. Amyloid. 2015;22(3):194-202. PMID: 26300107
7. Lee SJC, Choi TS, Lee JW, Lee HJ, Mun D, Akashi S, Lee SW, Lim MH, Kim HI. Structure and assembly mechanisms of toxic human islet amyloid polypeptide oligomers associated with copper. Chem Sci. 2016;22:5398-5406.
8. Lombardi A, Trimarco B, Iaccarino G, Santulli G. Impaired mitochondrial calcium uptake caused by tacrolimus underlies beta-cell failure. Cell Commun Signal. 2017;15(1):47. doi: 10.1186/s12964-017-0203-0. PMID: 29132395
9. Wong JC, Vo V, Gorjala P, Fiscus RR. Pancreatic-beta-cell survival and proliferation are promoted by protein kinase G type I-alpha and downstream regulation of AKT/FOXO1. Diab Vasc Dis Res. 2017;14(5):434-449. doi: 10.1177/1479164117713947. PMID: 28631500
10. Ji J, Petropavlovskaia M, Khatchadourian A, Patapas J, Makhlin J, Rosenberg L, Maysinger D. Type 2 diabetes is associated with suppression of autophagy and lipid accumulation in ??cells. J Cell Mol Med 2019 Feb 1. doi: 10.1111/jcmm.14172. PMID: 30710421
ECLASS 10.1 32160890
ECLASS 11.0 32160890
UNSPSC 41106509
Lieferbar
Description

Disease:

Insulinoma (Radiation induced cell immortalization)

Origin:

Pancreatic Islets

Species:

Rattus Norvegicus

Tissue:

Pancreas

Morphology:

beta cells

Properties:

Adherent

Medium:

AddexBio-Optimized RPMI-1640 Medium(C0004-02) + 10% FBS + 0.05 mM 2-mercaptoethanol

Subculture:

1:2 to 1:8 using 0.25% trypsin or trypsin/EDTA, 5% CO2; 37C

Freezing Medium:

Complete culture medium supplemented with 5% (v/v) DMSO

Biosafety Level:

I

Sterility:

Bacteria: Negative

Yeast: Negative

Mycoplasma: Negative

Pathogens:

HIV: Negative

Hepatitis B: Negative

Hepatitis C: Negative

Insulin Responsiveness:

Respond to glucose within the physiological range. Relatively high insulin content.

Related cells by Organ:

AR-42J cells

BxPc-3 cells

Capan-1 cells

MIA PaCa-2 cells

E3LZ10.7 cells

A10.7 cells

INS-1 cells

MIN-6 cells

INS-1E cells

Storage condition
LN2
Manufacturers Category
Cell Lines

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: One Frozen vial
Lieferbar: In stock
lieferbar

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