ArtNr |
AP1022-50ul |
Hersteller |
Abclonal
|
Menge |
50ul |
Kategorie |
|
Typ |
Antibody Monoclonal |
Applikationen |
WB, IF, IP, ICC, ELISA |
Specific against |
Human |
Host |
Rabbit |
Isotype |
IgG |
Konjugat/Tag |
Unconjugated |
Purity |
Affinity purification |
Sequence |
LMELQTYRYHGHSMSDPGVSYRTREEIQE |
NCBI |
PDHA1 |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Alias |
PDHA, PDHAD, PDHCE1A, PHE1A |
Similar products |
PHE1A, PDHA, PDHCE1A, PDHAD |
Lieferbar |
|
Background |
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Route |
Synthetic Peptide |
Manufacturers Category |
Phosphorylated Antibodies |
Immunogen |
A synthetic phosphorylated peptide around S293 of human PDHA1 (P08559). |
Storage |
Store at -20℃. Avoid freeze / thaw cycles.|Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
Recommended Dilution |
WB, 1:500 - 1:1000|IF/ICC, 1:50 - 1:200|IP, 1:500 - 1:1000 |
Protein Size |
43kDa |
Manufacturers Research Area |
Cancer, Signal Transduction, Endocrine Metabolism, Mitochondrial metabolism, Mitochondrial markers, Carbohydrate metabolism, Warburg Effect |
Gene Symbol |
PDHA1 |
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