ArtNr |
ABK-ABM40322-200ul |
Hersteller |
Abbkine Scientific
|
Menge |
200ul |
Kategorie |
|
Typ |
Antibody Monoclonal |
Applikationen |
Immunofluorescence, Western Blot, Immunohistochemistry |
Specific against |
Human, Mouse, Rat |
Host |
Mouse |
Isotype |
IgG1 |
ECLASS 10.1 |
42030590 |
ECLASS 11.0 |
42030590 |
UNSPSC |
12352203 |
Lieferbar |
|
Immunogen |
Synthetic Peptide of CHOP at AA range of 10-90 |
Applications notes |
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:1000-1:2000), IHC-P (1:100-1:200). |
Purification |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen |
Formulation |
Liquid solution |
Concentration |
1 mg/ml |
Storage buffer |
PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Storage instructions |
Stable for one year at -20C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing. |
Shipping |
Gel pack with blue ice. |
Precautions |
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product. |
Background |
DDIT3 (DNA damage inducible transcript 3) encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of DDIT3 and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. |
Gene ID |
1649 |
Alternative |
DDIT3 |
Other info |
CHOP protein detects endogenous levels of DDIT3. |
Accession |
P35638 |
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