Voltage-Dependent Anion-Selective Channel Protein 1 (VDAC1) Antibody

VDAC1 forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. The protein may participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.

PBS containing 0.09% sodium azide.

Calculated MW: 30.8 kDa

Purified Rabbit Polyclonal Antibody.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

VDAC1_HUMAN