Adapter Molecule Crk (CRK) Antibody

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins.The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction.The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.Two alternative transcripts encoding different isoforms with distinct biological activity have been described.

Unpurified ascites.

P46108

CRK

164762

Ascitic fluid containing 0.03% sodium azide.

This product is for research use only.