Proteasome Subunit Alpha Type 5 (PSMA5) Antibody

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. PMA5 is a member of the peptidase T1A family, that is a 20S core alpha subunit.

PBS containing 0.09% sodium azide.

Calculated MW: 26.4 kDa

Purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

PSA5_HUMAN